Jianan Qu
Ph.D, Chinese Academy of Sciences
Fellow, OSA
| Professor
Tel: (852) 2358-8541
Fax: (852) 2358-1485
E-mail: eequ@ust.hk
Office: Room 2426
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ACADEMIC EXPERIENCES AND QUALIFICATIONS:
1997 - present: Assistant/Associate/Full Professor, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology
2007 - 2010: Director of Postgraduate Programme, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology
Summer/2006: Invited Professor, Swiss Federal Institute of Technology (Ecole Polytechnique Federale de Lausanne), Switzerland
Summer/2005: Visiting Associate Professor, Beckmann Laser Institute and Department of Surgery, University of California, Irvine, USA
1995 - 1997: Staff Scientist, Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Canada.
1991 - 1994: Postdoctoral Research Associate, Department of Physics, University of California, Irvine, USA; British Columbia Cancer Research Center, Vancouver, Canada.
1986 - 1990: Ph.D in Optics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, China
RESEARECH INTERESTS:
Biophotonics; modern optical devices and systems; optical imaging processing; laser spectroscopy; environmental monitoring.
PROFESSIONAL ACTIVITIES:
Editorship:
Topical editor, Optics Letters (2010-)
Editorial board, Journal of Biomedical Optics (2010-)
Editorial board, International Journal of Optics, (2008-)
Editorial board, Chinese Journal of Lasers (2008-)
Professional affiliation:
Fellow, The Optical Society of America (OSA)
Member, The Society of Photo-Optical Instrumentation Engineers (SPIE)
Conference organization (major international conferences):
Member of program committee, Topical Meeting on Biomedical Optics, Optical Society of America, April 29- May 2, 2012, Miami, Florida, USA (2012)
Theme chair, 11th OWLS Optics Within Life Sciences: Optics-based Therapeutics, Diagnostics and Analytics, September 28-30, 2010, Quebec City, Canada (2010)
Member of program committee, Advanced Medical Imaging Technologies, Conference on Advanced Biomedical and Clinical Diagnostic Systems, Society of Photo-Optical Instrumentation Engineers, San Jose, USA (2009-2012)
Member of international advisory committee, Optics Within Life Sciences-10, July 2-4, 2008, Singapore (2008)
Member of international program committee, International Conference on Biomedical Engineering (BioMed), Innsbruck, Austria (2004-2006, 2012)
Member of program committee, Medical and Biological Applications, The Annual Conference on Lasers and Electro-Optics (CLEO), IEEE/LEOS (Lasers and Electro-Optics Society) and Optical Society of America, USA (2003-2004, 2011-2012)
Member of executive committee, European Conference on Biomedical Optics, Munich, Germany (2003)
Member of program committee, Conference of Diagnostic Optical Spectroscopy in Biomedicine, Optical Society of America and Society of Photo-Optical Instrumentation Engineers, Munich, Germany (2001, 2003)
Referee for scientific journals:
Analytical Chemistry, Applied Optics, Applied Spectroscopy, IEEE Journal of Selected Topics in Quantum Electronics, Journal of Biomedical Optics, Journal of Cancer Detection and Prevention, Journal of Optical Society of America-B, Journal of Raman Spectroscopy, Lasers in Surgery and Medicine, Optics Letters, Optics Express, Photochemistry and Photobiology
Selected Publications (peer-reviewed journals)
- Yan Zeng, Bo Yan, Qiqi Sun, Seng Khoon Teh, Wei Zhang, Zilong Wen, and Jianan Y. Qu, "Label-free in vivo imaging of human leukocytes using two-photon excited endogenous fluorescence", Journal of Biomedical Optics, V.18, 040103 (2013) PDF
- Seng Khoon Teh, Wei Zheng, Shuxia Li, Dong Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qu, "Multimodal nonlinear optical microscopy improves the accuracy of early diagnosis of squamous intraepithelial neoplasia", Journal of Biomedical Optics, V.18, 036001 (2013) PDF
- Yan Zeng, Yun Wu, Dong Li, Wei Zheng, Wen-Xiong Wang and Jianan Y. Qu, "Two-photon excitation chlorophyll fluorescence lifetime imaging: a rapid and noninvasive method for in vivo assessment
of cadmium toxicity in a marine diatom Thalassiosira weissflogii", Planta, Published online: 18 July, 2012 PDF
- Yan Zeng, Jin Xu, Dong Li, Li Li, Zilong Wen, and Jianan Y. Qu, "Label-free in vivo flow cytometry in zebrafish using two-photon autofluorescence imaging", Optics Letters, V.37, 2490-2492 (2012) PDF
- Liguo Jiang, Yan Zeng, Hongbo Zhou, Jianan Y. Qu, Shuhuai Yao, "Visualizing millisecond chaotic mixing dynamics in microdroplets: A direct comparison of experiment and simulation", Biomicrofluidics, V.6, 012810 (2012) PDF
- Yun Wu, Yan Zeng, Jianan Y. Qu, Wen-Xiong Wang, "Mercury effects on Thalassiosira weissflogii: Applications of two-photon excitation chlorophyll fluorescence lifetime imaging and flow cytometry", Aquatic Toxicology, V. 110-111, 133-140 (2012) PDF
- Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang and Jianan Y. Qu, "Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer", Optics Letters, V.36, 3620-3623 (2011) PDF
- Dong Li, Wei Zheng, Wei Zhang, Seng Khoon Teh, Yan Zeng, Yi Luo and Jianan Y. Qu, "Time-resolve detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue", Optics Letters, V.36, 2638-2640 (2011) PDF
- Yan Zeng, Liguo Jiang, Wei Zheng, Dong Li, Shuhuai Yao and Jianan Y. Qu, "Quantitative imaging of mixing dynamics in microfluidic droplets using two-photon fluorescence lifetime imaging", Optics Letters, V.36, 2236 (2011) PDF
- Dong Li, Wei Zheng, Yan Zeng, Yi Luo and Jianan Y. Qu, "Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo ", Optics Letters, V.36, 834-836 (2011) PDF
Fig. 2 (movie 1)
Fig. 3 (movie 2)
Fig. 3 (movie 3)
- Wei Zheng, Dong Li, Yan Zeng, Yi Luo and Jianan Y. Qu, "Two-photon excited hemoglobin fluorescence", Biomedical Optics Express, V.2, 71-79 (2011) PDF
- Dong Li, Wei Zheng, Yan Zeng and Jianan Y. Qu, "In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy", Applied Physics Letters, V.97, 223702 (2010) PDF
- Zhe Wang, Tao Wu, Lin Shi, Lin Zhang, Wei Zheng, Jianan Y. Qu, Ruifang Niu and Robert Z. Qi, "Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex", Journal of Biological Chemistry, V. 285, 22658 (2010) PDF
- Wei Zheng, Dong Li and Jianan Y. Qu, "Monitoring changes of cellular metabolism and micro-viscosity in vitro based on time-resolved endogenous fluorescence and its anisotropy decay dynamics", Journal of Biomedical Optics, V.15, 037013 (2010) PDF
- Tao Wu, Tak-Hong Cheung, So-Fan Yim and Jianan Y. Qu, "Clinical study of quantitative diagnosis of early cervical cancer based on the classification of acetowhitening kinetics", Journal of Biomedical Optics, V.15, 026001 (2010) PDF
- Dong Li, Wei Zheng and Jianan Y. Qu, "Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals", Optics Letters, V.34, 2853-2855 (2009) PDF
- Dong Li, Mildred S. Yang, Tao Lin, Wei Zheng and Jianan Y. Qu, "Study of cadmium induced cytotoxicity using two-photon excitation endogenous fluorescence microscopy", Journal of Biomedical Optics, V.14, 054028 (2009) PDF
- Dong Li, Wei Zheng and Jianan Y. Qu, "Two-photon autofluorescence microscopy of multicolor excitation", Optics Letters, V.34, 202-204 (2009)
PDF
- Dong Li, Wei Zheng and Jianan Y. Qu, "Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence", Optics Letters, V.33, 2365-2367 (2008)
PDF
- Wei Zheng, Yicong Wu, Dong Li and Jianan Y. Qu, "Epithelial autofluorescence: single- versus two-photon excitation", Journal of Biomedical Optics, V.13,
054010 (2008) PDF
- Tao T. Wu, Tak-Hong Cheung, So-Fan Yim and Jianan Y. Qu, "Optical imaging of cervical precancerous lesions based on active stereo vision and motion tracking",
Optics Express, V.16, 11224-11230 (2008) PDF
Fig. 3 (movie)
Fig. 4 (movie)
Fig. 5 (movie)
- M.S. Yang, D. Li, T. Lin, J.J. Zheng, W. Zheng and Jianan Y. Qu, "Increase in intracellular free/bound NAD[P]H as a cause of Cd-induced oxidative stress in the HepG2 cells
", Toxicology, V.247,
6-10 (2008) PDF
- Min Xu, Tao T. Wu and Jianan Y. Qu, "Unified Mie and fractal scattering by cells and experimental study on application in optical characterization of cellular and subcellular structures
", Journal of Biomedical Optics, V.13,
024015 (2008) PDF
- Tao T. Wu, Jianan Y. Qu and Min Xu, "Unified Mie and fractal scattering by biological
cells and subcellular structures", Optics Letters, Vol. 32, 2324-2326
(2007) PDF
- Tao T. Wu and Jianan Y. Qu, "Assessment of the relative contribution of
cellular components to the acetowhitening effect in cell cultures and suspensions
using elastic light-scattering spectroscopy", Applied Optics, V.46, 4834-4842
(2007) PDF
- Yicong Wu, Wei Zheng and Jianan Y. Qu, "Sensing cell metabolism by
time-resolved autofluorescence", Optics Letters, V.31, 3122-3124
(2006) PDF
- Yicong Wu and Jianan Y. Qu,, "Autofluorescence spectroscopy of
epithelial tissues", Journal of Biomedical Optics, V.11, 054023
(2006) PDF
- Yicong Wu and Jianan Y. Qu, "Combined depth- and time-resolved
autofluorescence spectroscopy of epithelial tissue", Optics
Letters, V.31, 1833-1835 (2006) PDF
- Yicong Wu and Jianan Y. Qu,, "Two-photon autofluorescence
spectroscopy and second harmonic generation of epithelial tissue",
Optics Letters, V.30, 3045-3047 (2005) PDF
- Tao T. Wu, Tak Hong Cheung, So Fan Yim, Yick Fu Wong and Jianan Y.
Qu, "Study of dynamic process of acetic acid induced whitening in
epithelial tissues at cellular level", Optics Express, V.13,
4963-4973 (2005) PDF
MOVIE1
MOVIE2
MOVIE3
- Yicong Wu, Peng Xi, Tak-Hong Cheung, Mei-Yung Yu and Jianan Y. Qu,
"Depth-resolved fluorescence spectroscopy of normal and dysplastic cervical
tissue", Optics Express, V.13, 382-388 (2005) PDF
MOVIE1
MOVIE2
- Yicong Wu, Peng Xi, Tak-Hong Cheung, Mei-Yung Yu and Jianan Y. Qu,
"Depth-resolved fluorescence spectroscopy reveals layered structure of
tissue", Optics Express, V.12, 3218-3223 (2004) PDF
- Wumei Lin, Powing Yuen, Xin Yuan, Jonathan Sham, Pengcheng Shi, William I.
Wei and Jianan Y. Qu, "Classification of in vivo autofluorescence
spectra using support vector machine", Journal of Biomedical
Optics, V.9, 180-186 (2004) PDF
- Manhong Chan, Wumei Lin, Changhe Zhou and Jianan Y. Qu, "A
miniaturized three-dimensional endoscopic imaging system based on active
stereovision", Applied Optics, V.42, 1888-1898 (2003) PDF
- Tao Wu, T. H. Cheung, K. W. Lo, Mei-Yung Yu and Jianan Y. Qu,
"Preliminary study of detecting neoplastic growth in vivo with real
time calibrated autofluorescence imaging", Optics Express, V.11,
291-298 (2003) PDF MOVIE
- Hanpeng Chang, Jianan Y. Qu, Powing Yuen, Jonathan Sham, Dora Kwang
and William I. Wei, "Light-induced autofluorescence spectroscopy for detection
of nasopharyngeal carcinoma in vivo", Applied
Spectroscopy, V.56, 1361-1367 (2002) PDF
- Jianan Y. Qu, Hanpeng Chang and Shenming Xiong, "Fluorescence
spectral imaging for characterization of tissue based on multivariate
statistical analysis", Journal of the Optical Society of America,
A, V.19, 1823-1831 (2002) PDF
- Jianan Y. Qu and Lan Shao, "Multiple band-pass-filtering method for
improvement on prediction accuracy of linear multivariate analysis",
Applied Spectroscopy, V.55, 1414-1421 (2001) PDF
- Jianan Y. Qu, Hanpeng Chang and Shenming Xiong, "Optical processing
of light induced autofluorescence for characterization of tissue pathology",
Optics Letters, V.26,1268-1270 (2001) PDF
- Jianan Y. Qu and Jianwen Hua, "Calibrated fluorescence imaging of
tissue in vivo", Applied Physics Letters,
V.78,4040-4042(2001) PDF
- Jianan Y. Qu and Lan Shao, "Near-IR Raman instrument for rapid and
quantitative measurements of clinically important analytes", Review of
Scientific Instruments, V.72 2717-2723 (2001) PDF
- Jianan Y. Qu, Zhijian Huang and Jianwen Hua, "Excitation and
collection geometry insensitive fluorescence imaging of tissue-simulating
turbid media", Applied Optics, V. 39, 3344-3356 (2000) PDF
- Jianan Y. Qu, Po Wing Yuen, Zhijian Huang, Dora Kwong, Jonathan
Sham, Siu Lung Lee, Wai Kuen Ho, and William I. Wei, "Preliminary Study of
in vivo Autofluorescence of Nasopharyngeal Carcinoma and Normal
Tissue", Lasers in Surgery and Medicine, V. 26, 432-440
(2000) PDF
- Jianan Y. Qu, Jianwen Hua and Zhijian Huang, "Correction of
Geometrical Effects on Fluorescence Imaging of Tissue" Optics
Communications (Full Length Paper), V. 176, 319-326 (2000) PDF
- Jianan Y. Qu, Zhijian Huang, and Jianwen Hua, "Mapping the
fluorescence yield on turbid media", Applied Physics Letters,
V.76, 970-972 (2000) PDF
Representative invited talks (selected from over 40 invited talks and lectures)
- "Two-photon Excited Blood Autofluorescence for In Vivo Imaging and Flow Cytometry",
Topical Meeting on Biomedical Optics, Optical Society of America, April 29- May 2, 2012, Miami, Florida, USA
- "Two-photon excited hemoglobin fluorescence for label-free imaging of microvasculature",
COLD SPRING HARBOR ASIA CONFERENCES: New Advances in Optical Imaging of Live Cells and Organisms, May 9 - 13, 2011, Suzhou, China
- "Seeing is believing: label-free bioanalytical imaging and microscopy",
11th OWLS Optics Within Life Sciences: Optics-based Therapeutics, Diagnostics and Analytics, September 28-30, 2010, Quebec City, Canada
- "Nonlinear optical microscopy of multi-color excitations from ultrafast supercontinuum generation: in vivo imaging of living cells and tissues",
Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, June 28-July 02, 2009, Burlington, Vermont, USA
- "Quantitative imaging of early cervical cancer: technology and mechanism",
Conference on Biomedical Applications of Light Scattering III, BiOS' 09, Jan. 24-29, 2009, San Jose, California, USA
- "Monitoring cellular metabolic pathways by wavelength- and time-resolved intracellular autofluorescence",
European Conferences on Biomedical Optics, June 17-21, 2007, Munich, Germany
- "Time-resolved autofluorescence and autofluorescence spectroscopy",
Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, June 10-14, 2007, Naples, Florida, USA
- "Fluorescence spectroscopy and imaging of biological tissues in vivo",
International Symposium on Biophotonics (Biophotonics 2004), June 21-24, 2004, Stockholm, Sweden
- "Advances in calibrated fluorescence imaging of pre-malignant lesions in vivo",
Annual International Conference on Advanced Laser Technology (ALT' 03, Focused on Biomedical Optics), 19-23 September 2003, Silsoe, UK
- "Fluorescence spectral imaging for characterization of tissue based on multivariate statistical analysis",
the Second International Conference on Biomedical Spectroscopy (from the bench to the clinic), 5-8 July 2003, Kings College, London, UK
- "Real time calibrated fluorescence imaging of tissue in vivo by using the combination of fluorescence and cross-polarized reflection",
Topical Meeting on Biomedical Optical Spectroscopy and Diagnostics, Optical Society of America, April 7-10, 2002, Miami Beach, Florida, USA
Patents
- Jianan Y. Qu, "Method and Apparatus for Fluorescence Imaging of
Tissue", US Patent No.6,343,228 (2002)
- Tao Wu and Jianan Y. Qu, "Apparatus and method for optical imaging for medical diagnosis", US Patent (2012)