CMOS Image Sensing: From Optoelectronic Microsystem to Disease Diagnostics

Dr. Derek Ho
Assistant Professor
Department of Physics and Materials Science
City University of Hong Kong

 :  23 Oct 2013 (Wed)
 :  11:00am - 12:00 noon
Venue  :  Classroom 2405 (via Lifts 17/18)

DNA analysis has become an indispensable research tool in medicine, enabling the investigation of relationships among genes, proteins, and drugs. Optical DNA analysis techniques such as fluorescence offer high sensitivity and selectivity. However conventional optical bio-instrumentation involves complex optics, inflexible detectors, and low level of integration, resulting in expensive and bulky systems.
This talk presents device, circuit, and microsystem integration techniques for CMOS image sensing as enabling technologies for DNA analysis based point-of-care medical diagnostic applications. Innovation in tunable-spectral sensing, dynamic range extension, and lensless imaging will be discussed. Measurement results of several fully-functional prototypes will be presented, in particular, from a fluorescence imaging biosensor demonstrating the detection of gene sequences for a spinal disease and the E. coli bacteria.
Derek Ho received his B.A.Sc. (first class) in Computer Engineering from the University of British Columbia (UBC), Vancouver, Canada in 2005. He received his M.A.Sc. from UBC in 2007, specializing in radio-frequency integrated circuits. He received his Ph.D. from the Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada in 2013.
Derek has held several engineering internships, including at PMC-Sierra, Burnaby, BC, Canada, where he participated in the development of communication integrated circuits.
He is currently an assistant professor in the Department of Physics and Materials Science at the City University of Hong Kong.
Derek’s research interests are highly interdisciplinary. He is especially interested in sensors research that incorporates electronics, signal processing, imaging, spectroscopy, microfluidics, chemistry, and biology. His current research emphasis includes micro- and nano-electronic devices, circuits, and systems for applications such as optical, chemical, and electrical biosensing, lenseless microscopy, lab-on-a-chip, and rapid medical diagnostics.
Atoms-to-Systems Laboratory: